5U8S
Structure of eukaryotic CMG helicase at a replication fork
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA replication complex GINS protein PSF1 | polymer | 208 | 24230.6 | 1 | UniProt (Q12488) Pfam (PF05916) Pfam (PF24997) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Partner of Sld five 1 |
| 2 | B (B) | DNA replication complex GINS protein PSF2 | polymer | 213 | 25096.8 | 1 | UniProt (P40359) Pfam (PF25005) Pfam (PF05916) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Partner of Sld five 2 |
| 3 | C (C) | DNA replication complex GINS protein PSF3 | polymer | 194 | 21977.1 | 1 | UniProt (Q12146) Pfam (PF22466) Pfam (PF05916) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Partner of Sld five 3 |
| 4 | D (D) | DNA replication complex GINS protein SLD5 | polymer | 294 | 33983.6 | 1 | UniProt (Q03406) Pfam (PF05916) Pfam (PF16922) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 5 | E (E) | Cell division control protein 45 | polymer | 650 | 74324.8 | 1 | UniProt (Q08032) Pfam (PF02724) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 6 | F (F) | DNA (26-MER) | polymer | 26 | 7930.1 | 1 | synthetic construct | ||
| 7 | G (G) | DNA (5'-D(P*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*CP*GP*AP*T)-3') | polymer | 14 | 4279.8 | 1 | synthetic construct | ||
| 8 | H (2) | DNA replication licensing factor MCM2 | polymer | 868 | 98911.5 | 1 | UniProt (P29469) Pfam (PF12619) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Minichromosome maintenance protein 2 |
| 9 | I (3) | DNA replication licensing factor MCM3 | polymer | 971 | 107653.5 | 1 | UniProt (P24279) Pfam (PF22207) Pfam (PF23191) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Minichromosome maintenance protein 3 |
| 10 | J (4) | DNA replication licensing factor MCM4 | polymer | 933 | 105096.3 | 1 | UniProt (P30665) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF21128) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Cell division control protein 54 |
| 11 | K (5) | Minichromosome maintenance protein 5 | polymer | 775 | 86505.7 | 1 | UniProt (P29496) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF21933) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Cell division control protein 46 |
| 12 | L (6) | DNA replication licensing factor MCM6 | polymer | 1017 | 113110.2 | 1 | UniProt (P53091) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF18263) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Minichromosome maintenance protein 6 |
| 13 | M (7) | DNA replication licensing factor MCM7 | polymer | 845 | 95049.9 | 1 | UniProt (P38132) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF24901) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Cell division control protein 47,Minichromosome maintenance protein 7 |
| 14 | N, O, P (2, 3, 5) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 3 | Chemie (ATP) |
Sequence modifications
4: 1 - 933 (UniProt: P30665)
| PDB | External Database | Details |
|---|---|---|
| Val 469 | Lys 468 | conflict |
| Ser 470 | Val 469 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 13 |
| Total formula weight | 798150.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1521.5 | |
| All* | Total formula weight | 799671.6 |
