5U7L
PDE2 catalytic domain complexed with inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | cGMP-dependent 3',5'-cyclic phosphodiesterase | polymer | 345 | 40225.1 | 3 | UniProt (O00408) Pfam (PF00233) | Homo sapiens (Human) | Cyclic GMP-stimulated phosphodiesterase,cGSPDE |
| 2 | D, G, J (A, B, C) | (3R)-1-{3-[5-(4-ethylphenyl)-1-methyl-1H-pyrazol-4-yl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}-N,N-dimethylpyrrolidin-3-amine | non-polymer | 430.5 | 3 | Chemie (7Y4) | |||
| 3 | E, H, K (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | F, I, L (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | M, N, O (A, B, C) | water | water | 18.0 | 181 | Chemie (HOH) |
Sequence modifications
A, B, C: 579 - 919 (UniProt: O00408)
| PDB | External Database | Details |
|---|---|---|
| Gly 575 | - | expression tag |
| Ser 576 | - | expression tag |
| Ala 577 | - | expression tag |
| Met 578 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 120675.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1560.8 | |
| All* | Total formula weight | 122236.1 |
