5U62
Crystal structure of EED in complex with H3K27Me3 peptide and 6-(benzo[d][1,3]dioxol-4-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Polycomb protein EED | polymer | 367 | 42356.2 | 2 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (Human) | hEED,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 2 | C, D (C, D) | Histone-lysine N-methyltransferase EZH2 | polymer | 30 | 3751.3 | 2 | UniProt (Q15910) Pfam (PF11616) | Homo sapiens | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 3 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G (A) | YTTRIUM (III) ION | non-polymer | 88.9 | 2 | Chemie (YT3) | |||
| 5 | H, I (A, B) | (6S)-6-[(2H-1,3-benzodioxol-4-yl)methyl]-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine | non-polymer | 271.3 | 2 | Chemie (7WD) | |||
| 6 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 800 | Chemie (HOH) |
Sequence modifications
A, B: 76 - 441 (UniProt: O75530)
| PDB | External Database | Details |
|---|---|---|
| Gly 75 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 92215.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 812.5 | |
| All* | Total formula weight | 93027.7 |
