5U2S
Pre-catalytic ternary complex of Human DNA Polymerase Beta With Gapped DNA substrate incoming (-)3TC-TP and Ca2+.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase beta | polymer | 343 | 39258.8 | 1 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (Human) | |
| 2 | B (D) | 5-MER PHOSPHORYLATED DOWNSTREAM PRIMER | polymer | 5 | 1536.0 | 1 | synthetic construct | ||
| 3 | C (P) | 10- MER PRIMER | polymer | 10 | 3061.0 | 1 | synthetic construct | ||
| 4 | D (T) | 16- MER TEMPLATE | polymer | 16 | 4869.2 | 1 | synthetic construct | ||
| 5 | E (A) | Lamivudine Triphosphate | non-polymer | 469.2 | 1 | Chemie (1RZ) | |||
| 6 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | G, H, I, P (A) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 8 | J, K, L, M, N... (A) | ACETATE ION | non-polymer | 59.0 | 6 | Chemie (ACT) | |||
| 9 | Q, R, S, T (A, D, P, T) | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A: 1 - 335 (UniProt: P06746)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Gly 0 | - | expression tag |
| His 336 | - | expression tag |
| His 337 | - | expression tag |
| His 338 | - | expression tag |
| His 339 | - | expression tag |
| His 340 | - | expression tag |
| His 341 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 48725.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 955.5 | |
| All* | Total formula weight | 49680.5 |
