5U1M

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Insulin receptor substrate 1	polymer	105	11832.8	1	UniProt (P35568) Pfam (PF02174) In PDB	Homo sapiens (Human)	IRS-1
2	B	Insulin receptor	polymer	10	1091.1	1	UniProt (P06213) In PDB	Homo sapiens (Human)	IR
3		water	water		18.0	120	Chemie (HOH)

Sequence modifications

A: 161 - 265 (UniProt: P35568)

PDB	External Database	Details
Ala 263	Glu 263	conflict

B: 1001 - 1009 (UniProt: P06213)

PDB	External Database	Details
Ace 1000	-	acetylation
Ala 1008	Glu 998	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	12923.8
All*	Total formula weight	12923.8

*Water molecules are not included.