5TZA
CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A WITH 3-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl-1-[(naphthalene-2-yl)carbonyl]piperidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cGMP-dependent 3',5'-cyclic phosphodiesterase | polymer | 344 | 40168.1 | 4 | UniProt (O00408) Pfam (PF00233) | Homo sapiens (Human) | Cyclic GMP-stimulated phosphodiesterase,cGSPDE |
| 2 | E, H, K, N (A, B, C, D) | [(3S)-3-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl](naphthalen-2-yl)methanone | non-polymer | 371.4 | 4 | Chemie (7OG) | |||
| 3 | F, I, L, O (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | G, J, M, P (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 1182 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 579 - 919 (UniProt: O00408)
| PDB | External Database | Details |
|---|---|---|
| Ser 576 | - | expression tag |
| Ala 577 | - | expression tag |
| Met 578 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 160672.2 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1844.6 | |
| All* | Total formula weight | 162516.8 |
