5TX9
Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with ceftobiprole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Penicillin-binding protein 4 | polymer | 359 | 40203.4 | 2 | UniProt (A0A0H2WY27) Pfam (PF00144) Pfam (PF00768) Pfam (PF09211) | Staphylococcus aureus (strain COL) | |
| 2 | C, D, H, I (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | E, J (A, B) | (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | non-polymer | 536.6 | 2 | Chemie (RB6) | |||
| 4 | F, G, K, L (A, B) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 5 | M, N (A, B) | water | water | 18.0 | 711 | Chemie (HOH) |
Sequence modifications
A, B: 25 - 383 (UniProt: A0A0H2WY27)
| PDB | External Database | Details |
|---|---|---|
| Ala 183 | Glu 183 | engineered mutation |
| Arg 241 | Phe 241 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80406.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1426.8 | |
| All* | Total formula weight | 81833.6 |
