5TUZ

Structure of human GLP SET-domain (EHMT1) in complex with inhibitor MS0124

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Histone-lysine N-methyltransferase EHMT1	polymer	261	30232.4	2	UniProt (Q9H9B1) Pfam (PF05033) Pfam (PF00856)	Homo sapiens (Human)	Euchromatic histone-lysine N-methyltransferase 1,Eu-HMTase1,G9a-like protein 1,GLP1,Histone H3-K9 methyltransferase 5,H3-K9-HMTase 5,Lysine N-methyltransferase 1D
2	C, J (A, B)	S-ADENOSYLMETHIONINE	non-polymer		398.4	2	Chemie (SAM)
3	D, E, F, G, K... (A, B)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
4	H, O (A, B)	6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(morpholin-4-yl)quinazolin-4-amine	non-polymer		387.5	2	Chemie (7L6)
5	I, P (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	Q, R (A, B)	water	water		18.0	340	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	60464.7
Non-Polymers*	Number of molecules	14
	Total formula weight	2219.2
All*	Total formula weight	62684.0

*Water molecules are not included.