5TTG
Crystal structure of catalytic domain of GLP with MS012
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase EHMT1 | polymer | 287 | 32974.3 | 2 | UniProt (Q9H9B1) Pfam (PF05033) Pfam (PF00856) | Homo sapiens (Human) | Euchromatic histone-lysine N-methyltransferase 1,Eu-HMTase1,G9a-like protein 1,GLP1,Histone H3-K9 methyltransferase 5,H3-K9-HMTase 5,Lysine N-methyltransferase 1D |
| 2 | C, Q (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 3 | D, R (A, B) | N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine | non-polymer | 401.5 | 2 | Chemie (7KZ) | |||
| 4 | E, F, G, H, S... (A, B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 5 | I (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | J (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | AA, BA, CA, DA, EA... (B, A) | UNKNOWN ATOM OR ION | non-polymer | 15 | Chemie (UNX) | ||||
| 8 | W (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 9 | GA, HA (A, B) | water | water | 18.0 | 633 | Chemie (HOH) |
Sequence modifications
A, B: 982 - 1266 (UniProt: Q9H9B1)
| PDB | External Database | Details |
|---|---|---|
| Gly 980 | - | expression tag |
| Ser 981 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65948.7 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 2328.9 | |
| All* | Total formula weight | 68277.6 |
