5TRI
CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 3-[(4-chlorophenyl)methoxy]-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | NS5B RNA-DEPENDENT RNA POLYMERASE | polymer | 574 | 63961.5 | 2 | UniProt (Q9WMX2) Pfam (PF00998) In PDB | Hepatitis C virus (HCV) | |
2 | A, B | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid | non-polymer | 630.7 | 2 | Chemie (23E) | |||
3 | A, B | 3-[(4-chlorophenyl)methoxy]-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid | non-polymer | 393.8 | 2 | Chemie (7HM) | |||
4 | A, B | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
5 | water | water | 18.0 | 470 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 573 (UniProt: Q9WMX2)
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 127923.0 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2817.6 | |
All* | Total formula weight | 130740.6 |