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5TR6

Discovery of TAK-659, an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ATyrosine-protein kinase SYKpolymer28933697.81UniProt (P43405)
Pfam (PF07714)
In PDB
Homo sapiens (Human)Spleen tyrosine kinase,p72-Syk
2A6-{[(1R,2S)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-onenon-polymer344.41Chemie (7KG)
3A1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
4waterwater18.0132Chemie (HOH)
Sequence modifications
A: 356 - 635 (UniProt: P43405)
PDBExternal DatabaseDetails
Met 353-initiating methionine
Ala 354-expression tag
Leu 355-expression tag
His 636-expression tag
His 637-expression tag
His 638-expression tag
His 639-expression tag
His 640-expression tag
His 641-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight33697.8
Non-Polymers*Number of molecules2
Total formula weight406.5
All*Total formula weight34104.3
*Water molecules are not included.

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PDB entries from 2024-09-18

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