5TPS
Structure of a Fc heterodimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Ig gamma-1 chain C region | polymer | 243 | 27004.4 | 1 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | B (A) | Ig gamma-1 chain C region | polymer | 232 | 25939.3 | 1 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (C) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1276.2 | 1 | In PDB GlyTouCan (G28663KH) | |||
| 4 | D (D) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 1 | In PDB GlyTouCan (G27919IH) | |||
| 5 | E, F (B, A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
B: 221 - 447 (UniProt: P01857)
A: 221 - 447 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Gly 216 | - | expression tag |
| Ser 217 | - | expression tag |
| Gly 218 | - | expression tag |
| Gly 219 | - | expression tag |
| Gly 220 | - | expression tag |
| Cys 349 | Tyr 232 | engineered mutation |
| Ser 366 | Thr 249 | engineered mutation |
| Ala 368 | Leu 251 | engineered mutation |
| Lys 405 | Phe 288 | engineered mutation |
| Val 407 | Tyr 290 | engineered mutation |
| Gly 448 | - | expression tag |
| Gly 449 | - | expression tag |
| Ser 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| His 455 | - | expression tag |
| His 456 | - | expression tag |
| His 457 | - | expression tag |
| His 458 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 216 | - | expression tag |
| Ser 217 | - | expression tag |
| Gly 218 | - | expression tag |
| Gly 219 | - | expression tag |
| Gly 220 | - | expression tag |
| Cys 354 | Ser 237 | engineered mutation |
| Trp 366 | Thr 249 | engineered mutation |
| Ala 409 | Lys 292 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52943.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2901.6 | |
| All* | Total formula weight | 55845.4 |
