5TOB
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein-tyrosine kinase 2-beta | polymer | 282 | 32579.8 | 1 | UniProt (Q14289) Pfam (PF07714) In PDB | Homo sapiens (Human) | Calcium-dependent tyrosine kinase,CADTK,Calcium-regulated non-receptor proline-rich tyrosine kinase,Cell adhesion kinase beta,CAKB,Focal adhesion kinase 2,FADK 2,Proline-rich tyrosine kinase 2,Related adhesion focal tyrosine kinase,RAFTK |
| 2 | A | N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | non-polymer | 507.5 | 1 | Chemie (YAM) | |||
| 3 | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A: 414 - 692 (UniProt: Q14289)
| PDB | External Database | Details |
|---|---|---|
| Gly 411 | - | expression tag |
| Ser 412 | - | expression tag |
| Met 413 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32579.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 507.5 | |
| All* | Total formula weight | 33087.2 |
