5TMM
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC analog, (E)-6-(4-((1R,4S,6R)-6-((4-bromophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenyl)hex-5-enoic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Estrogen receptor | polymer | 257 | 29299.5 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | C, D | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q15596) In PDB | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
3 | A, B | 6-{4-[(1S,4S,6S)-6-[(4-bromophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenyl}hex-5-enoic acid | non-polymer | 611.5 | 2 | Chemie (7M4) | |||
4 | water | water | 18.0 | 183 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 554 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
Ser 537 | Tyr 364 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 61758.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1223.0 | |
All* | Total formula weight | 62981.8 |