5TI9
Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural Genomics Consortium Target HR6161
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tryptophan 2,3-dioxygenase | polymer | 380 | 45182.5 | 4 | UniProt (P48775) Pfam (PF03301) | Homo sapiens (Human) | TDO,Tryptamin 2,3-dioxygenase,Tryptophan oxygenase,TRPO,Tryptophan pyrrolase,Tryptophanase |
| 2 | E, J (A, B) | OXYGEN MOLECULE | non-polymer | 32.0 | 2 | Chemie (OXY) | |||
| 3 | F, K, O, R (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 4 | G, H, L, M, Q... (A, B, C, D) | TRYPTOPHAN | non-polymer | 204.2 | 6 | Chemie (TRP) | |||
| 5 | I, N (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 6 | P, S (C, D) | N'-Formylkynurenine | non-polymer | 236.2 | 2 | Chemie (NFK) | |||
| 7 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 436 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 18 - 389 (UniProt: P48775)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | initiating methionine |
| Glu 390 | - | expression tag |
| His 391 | - | expression tag |
| His 392 | - | expression tag |
| His 393 | - | expression tag |
| His 394 | - | expression tag |
| His 395 | - | expression tag |
| His 396 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 180730.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4417.7 | |
| All* | Total formula weight | 185147.8 |
