5TH9
Structure determination of a potent, selective antibody inhibitor of human MMP9 (GS-5745 bound to MMP-9)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G (L, M, N) | GS-5745 Fab light chain | polymer | 214 | 23424.0 | 3 | Oryctolagus cuniculus | ||
| 2 | B, E, H (H, I, J) | GS-5745 Fab heavy chain | polymer | 230 | 24807.0 | 3 | Oryctolagus cuniculus | ||
| 3 | C, F, I (A, B, C) | Matrix metalloproteinase-9,Matrix metalloproteinase-9 | polymer | 231 | 25962.1 | 3 | UniProt (P14780) Pfam (PF00413) | Homo sapiens (Human) | MMP-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,GELB,MMP-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,GELB |
| 4 | J, K, O, P, T... (A, B, C) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 5 | L, M, Q, R, V... (A, B, C) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 6 | N, S, X (A, B, C) | COBALT HEXAMMINE(III) | non-polymer | 161.1 | 3 | Chemie (NCO) | |||
| 7 | AA, BA, CA, DA, Y... (A, M, I, B, L...) | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A, B, C: 40 - 215 (UniProt: P14780)
A, B, C: 391 - 443 (UniProt: P14780)
| PDB | External Database | Details |
|---|---|---|
| Met 38 | - | initiating methionine |
| Ala 39 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 222579.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1116.3 | |
| All* | Total formula weight | 223695.5 |
