5TGM

Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro

This is a large structure.

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
218S ribosomal RNApolymer1812583803.71
GenBank (CP006412.1)
Saccharomyces cerevisiae
S0, s040S ribosomal protein S0-Apolymer20622811.12
UniProt (B3LI22)
Pfam (PF00318)
Saccharomyces cerevisiae (Baker's yeast)Nucleic acid-binding protein NAB1A
S1, s140S ribosomal protein S1-Apolymer21624498.42
UniProt (B3RHV0)
Saccharomyces cerevisiae (Baker's yeast)
S2, s240S ribosomal protein S2polymer21723213.02
UniProt (P25443)
Pfam (PF00333)
Pfam (PF03719)
Saccharomyces cerevisiae (Baker's yeast)Omnipotent suppressor protein SUP44,RP12,S4,YS5
S3, s340S ribosomal protein S3polymer22324702.82
UniProt (P05750)
Pfam (PF00189)
Pfam (PF07650)
Saccharomyces cerevisiae (Baker's yeast)RP13,YS3
S4, s440S ribosomal protein S4-Apolymer26029338.12
UniProt (P0CX35)
Pfam (PF00467)
Pfam (PF00900)
Pfam (PF01479)
Pfam (PF08071)
Pfam (PF16121)
Saccharomyces cerevisiae (Baker's yeast)RP5,S7,YS6
S5, s540S ribosomal protein S5polymer20622908.32
UniProt (P26783)
Pfam (PF00177)
Saccharomyces cerevisiae (Baker's yeast)RP14,S2,YS8
S6, s640S ribosomal protein S6-Apolymer22625895.12
UniProt (P0CX37)
Pfam (PF01092)
Saccharomyces cerevisiae (Baker's yeast)RP9,S10,YS4
S7, s740S ribosomal protein S7-Apolymer18621158.62
UniProt (P26786)
Pfam (PF01251)
Saccharomyces cerevisiae (Baker's yeast)RP30,RP40
S8, s840S ribosomal protein S8polymer18821147.22
UniProt (A0A0J9X221)
Pfam (PF01201)
Saccharomyces cerevisiae (Yeast)
S9, s940S ribosomal protein S9-Apolymer18521210.72
UniProt (O13516)
Pfam (PF01479)
Saccharomyces cerevisiae (Baker's yeast)RP21,S13,YP28,YS11
C040S ribosomal protein S10-A,40S Ribosomal Protein S10polymer9611137.81
UniProt (Q08745)
Saccharomyces cerevisiae (Baker's yeast)
C1, c140S ribosomal protein S11-A,40S Ribosomal Protein S11polymer15517368.42
UniProt (P0CX47)
Pfam (PF00366)
Pfam (PF16205)
Saccharomyces cerevisiae (Baker's yeast)RP41,S18,YS12
C2, c240S Ribosomal Protein S12,40S ribosomal protein S12polymer12413239.32
UniProt (P48589)
Pfam (PF01248)
Saccharomyces cerevisiae
C3, c340S ribosomal protein S13polymer15016928.72
UniProt (P05756)
Pfam (PF00312)
Saccharomyces cerevisiae (Baker's yeast)S27a,YS15
C4, c440S ribosomal protein S14-Apolymer12813560.52
UniProt (P06367)
Saccharomyces cerevisiae (Baker's yeast)RP59A
C5, c540S Ribosomal Protein S15,40S ribosomal protein S15,40S Ribosomal Protein S15polymer13514977.62
UniProt (Q01855)
Pfam (PF00203)
Saccharomyces cerevisiaeRIG protein,RP52,S21,YS21
C6, c640S ribosomal protein S16-Apolymer14215746.32
UniProt (P0CX51)
Pfam (PF00380)
Saccharomyces cerevisiae (Baker's yeast)RP61R
C7ES17polymer12013769.01
UniProt (A0A0J9X224)
Pfam (PF00833)
Saccharomyces cerevisiae (Yeast)
C8, c840S ribosomal protein S18-Apolymer14516940.42
UniProt (P0CX55)
Pfam (PF00416)
Saccharomyces cerevisiae (Baker's yeast)
C9, c940S ribosomal protein S19-Apolymer14315810.92
UniProt (P07280)
Pfam (PF01090)
Saccharomyces cerevisiae (Baker's yeast)RP55A,S16a,YP45,YS16A
D0, d040S ribosomal protein S20polymer11012575.52
UniProt (P38701)
Pfam (PF00338)
Saccharomyces cerevisiae (Baker's yeast)
D1, d140S ribosomal protein S21-Apolymer879758.82
UniProt (P0C0V8)
Pfam (PF01249)
Saccharomyces cerevisiae (Baker's yeast)S26,YS25
D2, d240S ribosomal protein S22-Apolymer12914518.92
UniProt (P0C0W1)
Pfam (PF00410)
Saccharomyces cerevisiae (Baker's yeast)RP50,S24,YP58,YS22
D3, d340S ribosomal protein S23-Apolymer14415942.72
UniProt (P0CY39)
Pfam (PF00164)
Saccharomyces cerevisiae (Yeast)
D4, d440S ribosomal protein S24-Apolymer13415231.72
UniProt (P0CX31)
Pfam (PF01282)
Saccharomyces cerevisiae (Baker's yeast)RP50
D5, d540S ribosomal protein S25-Apolymer708001.42
UniProt (Q3E792)
Saccharomyces cerevisiae (Baker's yeast)RP45,S31,YS23
D6, d640S ribosomal protein S26-Bpolymer9711023.02
UniProt (P39939)
Saccharomyces cerevisiae (Baker's yeast)
D7, d740S ribosomal protein S27-Apolymer818762.22
UniProt (P35997)
Pfam (PF01667)
Saccharomyces cerevisiae (Baker's yeast)RP61,YS20
D8, d840S ribosomal protein S28-Apolymer637116.32
UniProt (Q3E7X9)
Pfam (PF01200)
Saccharomyces cerevisiae (Baker's yeast)S33,YS27
D9, d940S ribosomal protein S29-Apolymer536335.32
UniProt (P41057)
Pfam (PF00253)
Saccharomyces cerevisiae (Baker's yeast)S36,YS29
E0, e040S ribosomal protein S30-Apolymer627006.32
UniProt (P0CX33)
Pfam (PF04758)
Saccharomyces cerevisiae (Baker's yeast)
E1, e1Ubiquitin-40S ribosomal protein S31polymer768703.52
UniProt (P05759)
Pfam (PF01599)
Saccharomyces cerevisiae (Baker's yeast)
SRGuanine nucleotide-binding protein subunit beta-like proteinpolymer31834651.91
UniProt (P38011)
Pfam (PF00400)
Saccharomyces cerevisiae (Baker's yeast)Receptor for activated C kinase,Receptor of activated protein kinase C 1,RACK1
SMRibosome-bound protein Stm1,Suppressor protein STM1,Ribosome-bound protein Stm1polymer15916314.31
UniProt (P39015)
Saccharomyces cerevisiae3BP1,GU4 nucleic-binding protein 2,G4p2 protein,POP2 multicopy suppressor protein 4,Ribosomal subunits association factor,AF,TOM1 suppressor protein 1,Triplex-binding protein 1
125S ribosomal RNApolymer31491017859.11
GenBank (CP006419.1)
Saccharomyces cerevisiae
3, 75S ribosomal RNApolymer12138951.12
GenBank (CP008434.1)
Saccharomyces cerevisiae
4, 85.8S ribosomal RNApolymer15850682.92
GenBank (AH013031.2)
Saccharomyces cerevisiae
L2, l260S ribosomal protein L2-Apolymer25227217.32
UniProt (P0CX45)
Pfam (PF00181)
Pfam (PF03947)
Saccharomyces cerevisiae (Baker's yeast)L5,RP8,YL6
L3, l360S ribosomal protein L3polymer38643719.62
UniProt (P14126)
Saccharomyces cerevisiae (Baker's yeast)Maintenance of killer protein 8,RP1,Trichodermin resistance protein,YL1
L4, l460S ribosomal protein L4-Apolymer36139027.92
UniProt (P10664)
Pfam (PF00573)
Pfam (PF14374)
Saccharomyces cerevisiae (Baker's yeast)L2,RP2,YL2
L5, l560S ribosomal protein L5polymer29633633.62
UniProt (P26321)
Pfam (PF14204)
Pfam (PF17144)
Saccharomyces cerevisiae (Baker's yeast)L1,L1a,Ribosomal 5S RNA-binding protein,YL3
L6, l660S ribosomal protein L6-Apolymer17519869.42
UniProt (Q02326)
Pfam (PF01159)
Saccharomyces cerevisiae (Baker's yeast)L17,RP18,YL16
L7, l760S ribosomal protein L7-Apolymer22325341.52
UniProt (P05737)
Pfam (PF00327)
Saccharomyces cerevisiae (Baker's yeast)L6,RP11,YL8
L860S ribosomal protein L8-Apolymer23325815.01
UniProt (P17076)
Pfam (PF01248)
Saccharomyces cerevisiae (Baker's yeast)L4,L4-2,L7a-1,Maintenance of killer protein 7,RP6,YL5
L9, l960S ribosomal protein L9-Apolymer19121605.12
UniProt (P05738)
Pfam (PF00347)
Saccharomyces cerevisiae (Baker's yeast)L8,RP24,YL11
M0, m060S ribosomal protein L10polymer22025279.32
UniProt (P41805)
Pfam (PF00252)
Saccharomyces cerevisiae (Baker's yeast)L9,Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein
M1, m160S ribosomal protein L11-Bpolymer16919266.12
UniProt (Q3E757)
Pfam (PF00281)
Pfam (PF00673)
Saccharomyces cerevisiae (Baker's yeast)L16,RP39,YL22
M3, m360S ribosomal protein L13-Apolymer19421956.32
UniProt (Q12690)
Pfam (PF01294)
Saccharomyces cerevisiae (Baker's yeast)
M4, m460S ribosomal protein L14-Apolymer13715063.92
UniProt (P36105)
Pfam (PF01929)
Saccharomyces cerevisiae (Baker's yeast)
M5, m560S ribosomal protein L15-Apolymer20324351.22
UniProt (P05748)
Pfam (PF00827)
Saccharomyces cerevisiae (Baker's yeast)L13,RP15R,YL10,YP18
M6, m660S ribosomal protein L16-Apolymer19722029.02
UniProt (P26784)
Pfam (PF00572)
Saccharomyces cerevisiae (Baker's yeast)L13a,L21,RP22,YL15
M7, m760S ribosomal protein L17-Apolymer18320458.32
UniProt (P05740)
Pfam (PF00237)
Saccharomyces cerevisiae (Baker's yeast)L20A,YL17
M8, m860S ribosomal protein L18-Apolymer18520478.12
UniProt (P0CX49)
Pfam (PF17135)
Saccharomyces cerevisiae (Baker's yeast)RP28
M9, m960S ribosomal protein L19-Apolymer18821631.12
UniProt (P0CX82)
Pfam (PF01280)
Saccharomyces cerevisiae (Baker's yeast)L23,RP15L,RP33,YL14
N0, n060S ribosomal protein L20-Apolymer17220478.92
UniProt (P0CX23)
Pfam (PF01775)
Saccharomyces cerevisiae (Baker's yeast)L18a
N1, n160S ribosomal protein L21-Apolymer15918148.12
UniProt (Q02753)
Saccharomyces cerevisiae (Baker's yeast)
N2, n260S ribosomal protein L22-Apolymer10011263.92
UniProt (P05749)
Saccharomyces cerevisiae (Baker's yeast)L1c,RP4,YL31
N3, n360S ribosomal protein L23-Apolymer13614362.82
UniProt (P0CX41)
Pfam (PF00238)
Saccharomyces cerevisiae (Baker's yeast)L17a,YL32
N460S ribosomal protein L24-Apolymer9811369.41
UniProt (P04449)
Pfam (PF01246)
Saccharomyces cerevisiae (Baker's yeast)L30,RP29,YL21
N5, n560S ribosomal protein L25polymer12113771.22
UniProt (P04456)
Pfam (PF00276)
Saccharomyces cerevisiae (Baker's yeast)RP16L,YL25,YP42'
N6, n660S ribosomal protein L26-Apolymer12614134.62
UniProt (P05743)
Pfam (PF00467)
Pfam (PF16906)
Saccharomyces cerevisiae (Baker's yeast)L33,YL33
N7, n760S ribosomal protein L27-Apolymer13515437.22
UniProt (P0C2H6)
Pfam (PF01777)
Saccharomyces cerevisiae (Baker's yeast)
N8, n860S ribosomal protein L28polymer14816630.52
UniProt (P02406)
Pfam (PF00828)
Saccharomyces cerevisiae (Baker's yeast)L27a,L29,RP44,RP62,YL24
N9, n960S ribosomal protein L29polymer586560.72
UniProt (P05747)
Pfam (PF01779)
Saccharomyces cerevisiae (Baker's yeast)YL43
O0, o060S ribosomal protein L30polymer10010902.72
UniProt (P14120)
Pfam (PF01248)
Saccharomyces cerevisiae (Baker's yeast)L32,RP73,YL38
O1, o160S ribosomal protein L31-Apolymer10912649.82
UniProt (P0C2H8)
Pfam (PF01198)
Saccharomyces cerevisiae (Baker's yeast)L34,YL28
O2, o260S ribosomal protein L32polymer12714478.12
UniProt (P38061)
Pfam (PF01655)
Saccharomyces cerevisiae (Baker's yeast)
O3, o360S ribosomal protein L33-Apolymer10612045.92
UniProt (P05744)
Pfam (PF01247)
Saccharomyces cerevisiae (Baker's yeast)L37,RP47,YL37
O4, o460S ribosomal protein L34-Apolymer11212608.82
UniProt (P87262)
Saccharomyces cerevisiae (Baker's yeast)
O5, o560S ribosomal protein L35-Apolymer11913811.42
UniProt (P0CX84)
Pfam (PF00831)
Saccharomyces cerevisiae (Baker's yeast)
O6, o660S ribosomal protein L36-Apolymer9911020.12
UniProt (P05745)
Pfam (PF01158)
Saccharomyces cerevisiae (Baker's yeast)L39,YL39
O7, o760S ribosomal protein L37-Apolymer879746.22
UniProt (P49166)
Pfam (PF01907)
Saccharomyces cerevisiae (Baker's yeast)L43,YL35,YP55
O8, o860S ribosomal protein L38polymer778714.42
UniProt (P49167)
Pfam (PF01781)
Saccharomyces cerevisiae (Baker's yeast)
O9, o960S ribosomal protein L39polymer506227.42
UniProt (P04650)
Pfam (PF00832)
Saccharomyces cerevisiae (Baker's yeast)L46,YL40
Q0, q0Ubiquitin-60S ribosomal protein L40polymer526032.32
UniProt (P0CH08)
Pfam (PF01020)
Saccharomyces cerevisiae (Baker's yeast)
Q1, q160S ribosomal protein L41-Apolymer253354.22
UniProt (P0CX86)
Pfam (PF05162)
Saccharomyces cerevisiae (Baker's yeast)L47,YL41
Q2, q260S ribosomal protein L42-Apolymer10512115.52
UniProt (P0CX27)
Pfam (PF00935)
Saccharomyces cerevisiae (Baker's yeast)L41,YL27,YP44
Q3, q360S ribosomal protein L43-Apolymer919981.82
UniProt (P0CX25)
Pfam (PF01780)
Saccharomyces cerevisiae (Baker's yeast)L37a,YL35
618S ribosomal RNApolymer1800579761.91
GenBank (CP006411.1)
Saccharomyces cerevisiae
c040S ribosomal protein S10-A,40S Ribosomal Protein S10polymer9611040.71
UniProt (Q08745)
Saccharomyces cerevisiae (Baker's yeast)
c7ES17polymer12113840.11
UniProt (A0A0J9X224)
Pfam (PF00833)
Saccharomyces cerevisiae (Yeast)
sRGuanine nucleotide-binding protein subunit beta-like proteinpolymer31834710.01
UniProt (P38011)
Pfam (PF00400)
Saccharomyces cerevisiae (Baker's yeast)Receptor for activated C kinase,Receptor of activated protein kinase C 1,RACK1
sMSuppressor protein STM1,Ribosome-bound protein Stm1polymer10410310.91
UniProt (P39015)
Saccharomyces cerevisiae (Baker's yeast)3BP1,GU4 nucleic-binding protein 2,G4p2 protein,POP2 multicopy suppressor protein 4,Ribosomal subunits association factor,AF,TOM1 suppressor protein 1,Triplex-binding protein 1
525S ribosomal RNApolymer31501018196.41
GenBank (CP006419.1)
Saccharomyces cerevisiae
l860S ribosomal protein L8-A,60S Ribosomal Protein L8polymer23125493.71
UniProt (P17076)
Pfam (PF01248)
Saccharomyces cerevisiae (Baker's yeast)L4,L4-2,L7a-1,Maintenance of killer protein 7,RP6,YL5
m260S Ribosomal Protein L12polymer15012783.81
Saccharomyces cerevisiae
n460S ribosomal protein L24-Apolymer13515506.21
UniProt (P04449)
Pfam (PF01246)
Saccharomyces cerevisiae (Baker's yeast)L30,RP29,YL21
p060S Ribosomal Protein P0polymer14315627.21
Saccharomyces cerevisiae
p1, p260S Ribosomal Protein P1/2polymer474017.92
Saccharomyces cerevisiae
P, pPeptidyl-tRNA analog ACCA-Leu-Phepolymer5740.62
Homo sapiens
osmium (III) hexamminenon-polymer286.41095
MAGNESIUM IONnon-polymer24.31191
ZINC IONnon-polymer65.416
PHENYLALANINEnon-polymer165.22
LEUCINEnon-polymer131.22
SPARSOMYCINnon-polymer361.42
3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate)non-polymer346.22

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains164
Total molecular weight5964445.7
Non-Polymers*Number of molecules2310
Total molecular weight345571.5
All*Total molecular weight6310017.3
*Water molecules are not included.