5TGD

Crystal structure of FolM Alternative dihydrofolate reductase 1 from Brucella suis in complex with NADP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	FolM Alternative dihydrofolate reductase	polymer	267	29693.8	4	UniProt (A0A0F6ITS6)	Brucella suis 92/29
2	E, H, I, K (A, B, C, D)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	4	Chemie (NAP)
3	F, J, L, M (A, C, D)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
4	G (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	N, O, P, Q (A, B, C, D)	water	water		18.0	743	Chemie (HOH)

Sequence modifications

A, B, C, D: 10 - 267 (UniProt: A0A0F6ITS6)

PDB	External Database	Details
Met 1	-	initiating methionine
Ala 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
Met 9	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	118775.2
Non-Polymers*	Number of molecules	9
	Total formula weight	3314.0
All*	Total formula weight	122089.1

*Water molecules are not included.