5TFC
Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cystic fibrosis transmembrane conductance regulator | polymer | 229 | 25525.4 | 1 | UniProt (P13569) Pfam (PF00005) | Homo sapiens (Human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 3 | C (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 4 | D (A) | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A: 387 - 646 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Ser 386 | - | expression tag |
| - | Phe 405 | deletion |
| - | Gly 406 | deletion |
| - | Glu 407 | deletion |
| - | Leu 408 | deletion |
| - | Phe 409 | deletion |
| - | Glu 410 | deletion |
| - | Lys 411 | deletion |
| - | Ala 412 | deletion |
| - | Lys 413 | deletion |
| - | Gln 414 | deletion |
| - | Asn 415 | deletion |
| - | Asn 416 | deletion |
| - | Asn 417 | deletion |
| - | Asn 418 | deletion |
| - | Arg 419 | deletion |
| - | Lys 420 | deletion |
| - | Thr 421 | deletion |
| - | Ser 422 | deletion |
| - | Asn 423 | deletion |
| - | Gly 424 | deletion |
| - | Asp 425 | deletion |
| - | Asp 426 | deletion |
| - | Ser 427 | deletion |
| - | Leu 428 | deletion |
| - | Phe 429 | deletion |
| - | Phe 430 | deletion |
| - | Ser 431 | deletion |
| - | Asn 432 | deletion |
| - | Phe 433 | deletion |
| - | Ser 434 | deletion |
| - | Leu 435 | deletion |
| - | Leu 436 | deletion |
| Met 470 | Val 470 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25525.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 547.5 | |
| All* | Total formula weight | 26072.9 |
