5TFC
Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with GTP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cystic fibrosis transmembrane conductance regulator | polymer | 229 | 25525.4 | 1 | UniProt (P13569) Pfam (PF00005) In PDB | Homo sapiens (Human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
3 | A | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
4 | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A: 387 - 646 (UniProt: P13569)
PDB | External Database | Details |
---|---|---|
Ser 386 | - | expression tag |
- | Phe 405 | deletion |
- | Gly 406 | deletion |
- | Glu 407 | deletion |
- | Leu 408 | deletion |
- | Phe 409 | deletion |
- | Glu 410 | deletion |
- | Lys 411 | deletion |
- | Ala 412 | deletion |
- | Lys 413 | deletion |
- | Gln 414 | deletion |
- | Asn 415 | deletion |
- | Asn 416 | deletion |
- | Asn 417 | deletion |
- | Asn 418 | deletion |
- | Arg 419 | deletion |
- | Lys 420 | deletion |
- | Thr 421 | deletion |
- | Ser 422 | deletion |
- | Asn 423 | deletion |
- | Gly 424 | deletion |
- | Asp 425 | deletion |
- | Asp 426 | deletion |
- | Ser 427 | deletion |
- | Leu 428 | deletion |
- | Phe 429 | deletion |
- | Phe 430 | deletion |
- | Ser 431 | deletion |
- | Asn 432 | deletion |
- | Phe 433 | deletion |
- | Ser 434 | deletion |
- | Leu 435 | deletion |
- | Leu 436 | deletion |
Met 470 | Val 470 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 25525.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 547.5 | |
All* | Total formula weight | 26072.9 |