5TFB
Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with 7-methyl-GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cystic fibrosis transmembrane conductance regulator | polymer | 229 | 25525.4 | 1 | UniProt (P13569) Pfam (PF00005) | Homo sapiens (Human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 538.2 | 1 | Chemie (MGP) | |||
| 4 | D (A) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 387 - 646 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Ser 386 | - | expression tag |
| - | Phe 405 | deletion |
| - | Gly 406 | deletion |
| - | Glu 407 | deletion |
| - | Leu 408 | deletion |
| - | Phe 409 | deletion |
| - | Glu 410 | deletion |
| - | Lys 411 | deletion |
| - | Ala 412 | deletion |
| - | Lys 413 | deletion |
| - | Gln 414 | deletion |
| - | Asn 415 | deletion |
| - | Asn 416 | deletion |
| - | Asn 417 | deletion |
| - | Asn 418 | deletion |
| - | Arg 419 | deletion |
| - | Lys 420 | deletion |
| - | Thr 421 | deletion |
| - | Ser 422 | deletion |
| - | Asn 423 | deletion |
| - | Gly 424 | deletion |
| - | Asp 425 | deletion |
| - | Asp 426 | deletion |
| - | Ser 427 | deletion |
| - | Leu 428 | deletion |
| - | Phe 429 | deletion |
| - | Phe 430 | deletion |
| - | Ser 431 | deletion |
| - | Asn 432 | deletion |
| - | Phe 433 | deletion |
| - | Ser 434 | deletion |
| - | Leu 435 | deletion |
| - | Leu 436 | deletion |
| Met 470 | Val 470 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25525.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 562.5 | |
| All* | Total formula weight | 26087.9 |
