5TE8
Crystal structure of the midazolam-bound human CYP3A4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Cytochrome P450 3A4 | polymer | 487 | 55757.8 | 3 | UniProt (P08684) Pfam (PF00067) | Homo sapiens (Human) | 1,8-cineole 2-exo-monooxygenase,Albendazole monooxygenase,Albendazole sulfoxidase,CYPIIIA3,CYPIIIA4,Cholesterol 25-hydroxylase,Cytochrome P450 3A3,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450-PCN1,Nifedipine oxidase,Quinine 3-monooxygenase,Taurochenodeoxycholate 6-alpha-hydroxylase |
| 2 | D, F, H (A, B, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 3 | Chemie (HEM) | |||
| 3 | E, G, I (A, B, C) | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine | non-polymer | 325.8 | 3 | Chemie (08J) | |||
| 4 | J, K, L (A, B, C) | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 503 (UniProt: P08684)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | see remark 999 |
| Ala 2 | - | see remark 999 |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 167273.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2826.8 | |
| All* | Total formula weight | 170100.2 |
