5TE0
Crystal Structure of Adaptor Protein 2 Associated Kinase (AAK1) in complex with BIBF 1120
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | AP2-associated protein kinase 1 | polymer | 347 | 39082.8 | 1 | UniProt (Q2M2I8) Pfam (PF00069) | Homo sapiens (Human) | Adaptor-associated kinase 1 |
| 2 | B (A) | methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate | non-polymer | 539.6 | 1 | Chemie (XIN) | |||
| 3 | C (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | D, E, F, G, H... (A) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 5 | L (A) | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A: 27 - 365 (UniProt: Q2M2I8)
| PDB | External Database | Details |
|---|---|---|
| Met 26 | - | initiating methionine |
| Ala 366 | - | expression tag |
| Glu 367 | - | expression tag |
| Asn 368 | - | expression tag |
| Leu 369 | - | expression tag |
| Tyr 370 | - | expression tag |
| Phe 371 | - | expression tag |
| Gln 372 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39082.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1382.5 | |
| All* | Total formula weight | 40465.3 |
