5TDI
Crystal structure of Cathepsin K with a covalently-linked inhibitor at 1.4 Angstrom resolution.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cathepsin K | polymer | 215 | 23507.5 | 1 | UniProt (P43235) Pfam (PF00112) | Homo sapiens (Human) | Cathepsin O,Cathepsin O2,Cathepsin X |
| 2 | B (A) | 4-fluoro-N-{1-[(Z)-iminomethyl]cyclopropyl}-N~2~-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl }-L-leucinamide | non-polymer | 527.6 | 1 | Chemie (7AS) | |||
| 3 | C (A) | water | water | 18.0 | 278 | Chemie (HOH) |
Sequence modifications
A: 1 - 215 (UniProt: P43235)
| PDB | External Database | Details |
|---|---|---|
| Ala 49 | Ser 163 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23507.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 527.6 | |
| All* | Total formula weight | 24035.1 |
