5TD2
Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase Mer | polymer | 285 | 32820.1 | 2 | UniProt (Q12866) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK |
| 2 | C (A) | N-[2-{4-[(2S)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}-4-(morpholin-4-yl)phenyl]-1H-imidazole-2-carboxamide | non-polymer | 518.6 | 1 | Chemie (7AE) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A, B: 577 - 861 (UniProt: Q12866)
| PDB | External Database | Details |
|---|---|---|
| Met 650 | Ile 650 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65640.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 518.6 | |
| All* | Total formula weight | 66158.9 |
