5TC7

Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 5'-methylthiotubercidin at 1.75 angstrom

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	S-methyl-5'-thioadenosine phosphorylase	polymer	297	33119.1	1	UniProt (Q13126) Pfam (PF01048)	Homo sapiens (Human)	5'-methylthioadenosine phosphorylase,MTAPase
2	B, C, D (A)	PHOSPHATE ION	non-polymer		95.0	3	Chemie (PO4)
3	E (A)	2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL	non-polymer		296.3	1	Chemie (MTH)
4	F (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	G (A)	water	water		18.0	189	Chemie (HOH)

Sequence modifications

A: 1 - 283 (UniProt: Q13126)

PDB	External Database	Details
Met -13	-	initiating methionine
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33119.1
Non-Polymers*	Number of molecules	5
	Total formula weight	616.7
All*	Total formula weight	33735.8

*Water molecules are not included.