5TC0
Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase Mer | polymer | 314 | 35994.6 | 2 | UniProt (Q12866) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK |
2 | A | N-(2-{4-[(2S)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}phenyl)-1H-imidazole-2-carboxamide | non-polymer | 433.5 | 1 | Chemie (79Y) | |||
3 | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A, B: 570 - 864 (UniProt: Q12866)
PDB | External Database | Details |
---|---|---|
Met 551 | - | initiating methionine |
Gly 552 | - | expression tag |
Ser 553 | - | expression tag |
Ser 554 | - | expression tag |
His 555 | - | expression tag |
His 556 | - | expression tag |
His 557 | - | expression tag |
His 558 | - | expression tag |
His 559 | - | expression tag |
His 560 | - | expression tag |
Ser 561 | - | expression tag |
Ser 562 | - | expression tag |
Gly 563 | - | expression tag |
Leu 564 | - | expression tag |
Val 565 | - | expression tag |
Pro 566 | - | expression tag |
Arg 567 | - | expression tag |
Gly 568 | - | expression tag |
Ser 569 | - | expression tag |
Met 650 | Ile 650 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 71989.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 433.5 | |
All* | Total formula weight | 72422.6 |