5TBC
PRECATALYTIC TERNARY COMPLEX OF HUMAN DNA POLYMERASE BETA WITH GAPPED DNA SUBSTRATE, INCORPORATED (-)3TC-MP AND AN ANOTHER INCOMING (-)3TC-TP NUCLEOTIDE.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase beta | polymer | 343 | 39258.8 | 1 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (Human) | |
| 2 | B (D) | 5-MER PHOSPHORYLATED DOWNSTREAM PRIMER | polymer | 5 | 1536.0 | 1 | Synthetic construct | ||
| 3 | C (P) | 10- MER PRIMER | polymer | 10 | 3061.0 | 1 | Synthetic construct | ||
| 4 | D (T) | 16- MER TEMPLATE | polymer | 16 | 4869.2 | 1 | Synthetic construct | ||
| 5 | E (A) | Lamivudine Triphosphate | non-polymer | 469.2 | 1 | Chemie (1RZ) | |||
| 6 | F, G, H, I, J... (A, T) | SODIUM ION | non-polymer | 23.0 | 6 | Chemie (NA) | |||
| 7 | K (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | L (A) | [(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl]methyl dihydrogen phosphate | non-polymer | 309.2 | 1 | Chemie (42E) | |||
| 9 | N, O, P, Q (A, D, P, T) | water | water | 18.0 | 252 | Chemie (HOH) |
Sequence modifications
A: 1 - 335 (UniProt: P06746)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Gly 0 | - | expression tag |
| His 336 | - | expression tag |
| His 337 | - | expression tag |
| His 338 | - | expression tag |
| His 339 | - | expression tag |
| His 340 | - | expression tag |
| His 341 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 48725.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 951.8 | |
| All* | Total formula weight | 49676.8 |
