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5TBC

PRECATALYTIC TERNARY COMPLEX OF HUMAN DNA POLYMERASE BETA WITH GAPPED DNA SUBSTRATE, INCORPORATED (-)3TC-MP AND AN ANOTHER INCOMING (-)3TC-TP NUCLEOTIDE.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ADNA polymerase betapolymer34339258.81UniProt (P06746)
Pfam (PF14716)
Pfam (PF10391)
Pfam (PF14792)
Pfam (PF14791)
In PDB
Homo sapiens (Human)
2D5-MER PHOSPHORYLATED DOWNSTREAM PRIMERpolymer51536.01Synthetic construct
3P10- MER PRIMERpolymer103061.01Synthetic construct
4T16- MER TEMPLATEpolymer164869.21Synthetic construct
5ALamivudine Triphosphatenon-polymer469.21Chemie (1RZ)
6A, TSODIUM IONnon-polymer23.06Chemie (NA)
7ACHLORIDE IONnon-polymer35.51Chemie (CL)
8A[(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl]methyl dihydrogen phosphatenon-polymer309.21Chemie (42E)
9waterwater18.0252Chemie (HOH)
Sequence modifications
A: 1 - 335 (UniProt: P06746)
PDBExternal DatabaseDetails
Met -1-initiating methionine
Gly 0-expression tag
His 336-expression tag
His 337-expression tag
His 338-expression tag
His 339-expression tag
His 340-expression tag
His 341-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight48725.0
Non-Polymers*Number of molecules9
Total formula weight951.8
All*Total formula weight49676.8
*Water molecules are not included.

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PDB entries from 2024-06-12

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