5TB8
Precatalytic ternary complex of Human DNA Polymerase Beta in closed conformation With Gapped DNA substrate incoming (-)3TC-TP and Mn2+.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase beta | polymer | 343 | 39258.8 | 1 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (Human) | |
| 2 | B (D) | 5-MER PHOSPHORYLATED DOWNSTREAM PRIME | polymer | 5 | 1536.0 | 1 | Synthetic construct | ||
| 3 | C (P) | 10- MER PRIMER | polymer | 10 | 3061.0 | 1 | Synthetic construct | ||
| 4 | D (T) | 16- MER TEMPLATE | polymer | 16 | 4869.2 | 1 | Synthetic construct | ||
| 5 | E (A) | Lamivudine Triphosphate | non-polymer | 469.2 | 1 | Chemie (1RZ) | |||
| 6 | F, G, H, I, J... (A) | MANGANESE (II) ION | non-polymer | 54.9 | 6 | Chemie (MN) | |||
| 7 | L, M, N, O, P (A) | SODIUM ION | non-polymer | 23.0 | 5 | Chemie (NA) | |||
| 8 | Q, R (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 9 | S, T, U, V, W... (A) | ACETATE ION | non-polymer | 59.0 | 6 | Chemie (ACT) | |||
| 10 | AA, BA, Y, Z (P, T, A, D) | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A: 1 - 335 (UniProt: P06746)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Gly 0 | - | expression tag |
| His 336 | - | expression tag |
| His 337 | - | expression tag |
| His 338 | - | expression tag |
| His 339 | - | expression tag |
| His 340 | - | expression tag |
| His 341 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 48725.0 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 1338.9 | |
| All* | Total formula weight | 50063.9 |
