5TA2
Discovery of a Potent Cyclophilin Inhibitor (Compound 7) based on Structural Simplification of Sanglifehrin A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Peptidyl-prolyl cis-trans isomerase A | polymer | 163 | 17776.2 | 1 | UniProt (P62937) Pfam (PF00160) In PDB | Homo sapiens (Human) | PPIase A,Cyclophilin A,Cyclosporin A-binding protein,Rotamase A |
| 2 | A | 11-[(3-hydroxyphenyl)methyl]-18-methoxy-2,17-dimethyl-14-(propan-2-yl)-3-oxa-9,12,15,28-tetraazatricyclo[21.3.1.1~5,9~]octacosa-1(27),21,23,25-tetraene-4,10,13,16-tetrone | non-polymer | 648.8 | 1 | BIRD (PRD_002246) Chemie (78X) | |||
| 3 | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17776.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 648.8 | |
| All* | Total formula weight | 18425.0 |
