5T97
ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH (2E)-3-(4-{(1R)-6-hydroxy-1-methyl-2-[4-(propan-2 -yl)phenyl]-1,2,3,4- tetrahydroisoquinolin-1-yl}phenyl)prop-2-enoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Estrogen receptor | polymer | 254 | 28897.9 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | A, B | (2E)-3-(4-{(1R)-6-hydroxy-1-methyl-2-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydroisoquinolin-1-yl}phenyl)prop-2-enoic acid | non-polymer | 427.5 | 2 | Chemie (782) | |||
| 3 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: 301 - 553 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Gly 300 | - | expression tag |
| Ser 381 | Cys 381 | conflict |
| Ser 417 | Cys 417 | conflict |
| Ser 530 | Cys 530 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57795.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 855.1 | |
| All* | Total formula weight | 58650.8 |
