5T2A
CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | LSU-alpha | polymer | 1781 | 576313.5 | 1 | GenBank (322500086) | Leishmania donovani | |
| 2 | B (B) | LSU-beta | polymer | 1465 | 471465.2 | 1 | Leishmania donovani | ||
| 3 | C (C) | 5.8S rRNA | polymer | 262 | 84351.8 | 1 | GenBank (79677111) | Leishmania donovani | |
| 4 | D (D) | 5S rRNA | polymer | 120 | 38532.9 | 1 | GenBank (361050153) | Leishmania donovani | |
| 5 | E (E) | srRNA1 | polymer | 213 | 68191.1 | 1 | GenBank (322500086) | Leishmania donovani | |
| 6 | F (F) | srRNA3 | polymer | 73 | 23361.0 | 1 | Leishmania donovani | ||
| 7 | G (G) | srRNA2 | polymer | 183 | 59084.0 | 1 | GenBank (5019758) | Leishmania donovani | |
| 8 | H (H) | srRNA4 | polymer | 127 | 40965.3 | 1 | GenBank (5019758) | Leishmania donovani | |
| 9 | I (I) | eL18 | polymer | 198 | 22071.1 | 1 | UniProt (E9BUI1) UniProt (by SIFTS) (A0A3S7XBN1) | Leishmania donovani | 60S ribosomal protein L18 |
| 10 | J (J) | uL16 | polymer | 213 | 24607.2 | 1 | UniProt (E9B840) UniProt (by SIFTS) (A0A3S5H5C4) | Leishmania donovani | 60S ribosomal protein L10 |
| 11 | K (K) | uL5 | polymer | 188 | 21710.5 | 1 | UniProt (E9BFL1) UniProt (by SIFTS) (A0A3S5H5A8) | Leishmania donovani | 60S ribosomal protein L11 (L5, L16) |
| 12 | L (L) | eL13 | polymer | 220 | 24831.0 | 1 | Leishmania donovani | ||
| 13 | M (M) | uL13 | polymer | 222 | 25479.2 | 1 | Leishmania donovani | ||
| 14 | N (N) | eL14 | polymer | 175 | 19935.5 | 1 | UniProt (Q25278) | Leishmania donovani | 60S ribosomal protein L14, 23 kDa cell surface protein,LDP 23 |
| 15 | O (O) | eL15 | polymer | 204 | 24498.0 | 1 | UniProt (E9BMB4) | Leishmania donovani | Ribosomal protein L15 |
| 16 | P (P) | uL22 | polymer | 166 | 19154.6 | 1 | UniProt (E9BGL6) UniProt (by SIFTS) (A0A3S7WY02) | Leishmania donovani | 60S ribosomal protein L17 |
| 17 | Q (Q) | eL20 | polymer | 179 | 20834.4 | 1 | UniProt (E9BRT7) UniProt (by SIFTS) (A0A3Q8II03) | Leishmania donovani | 60S ribosomal protein L18a |
| 18 | R (R) | eL19 | polymer | 245 | 28142.2 | 1 | UniProt (E9B8Q2) | Leishmania donovani | 60S ribosomal protein L19 |
| 19 | S (S) | eL21 | polymer | 159 | 18059.3 | 1 | UniProt (E9BRE2) UniProt (by SIFTS) (A0A3Q8ICH0) | Leishmania donovani | 60S ribosomal protein L21 |
| 20 | T (T) | eL22 | polymer | 129 | 15030.5 | 1 | UniProt (E9BU52) UniProt (by SIFTS) (A0A3Q8IJA8) | Leishmania donovani | 60S ribosomal protein L22 |
| 21 | U (U) | uL14 | polymer | 139 | 14982.6 | 1 | UniProt (E9BSQ4) UniProt (by SIFTS) (A0A3Q8IIA7) | Leishmania donovani | 60S ribosomal protein L23 |
| 22 | V (V) | uL23 | polymer | 145 | 16306.3 | 1 | UniProt (D1M863) | Leishmania donovani | 60S ribosomal protein L23a |
| 23 | W (W) | eL24 | polymer | 124 | 14608.2 | 1 | Leishmania donovani | ||
| 24 | X (X) | uL24 | polymer | 143 | 16224.2 | 1 | Leishmania donovani | ||
| 25 | Y (Y) | eL27 | polymer | 134 | 15455.3 | 1 | UniProt (E9BP34) | Leishmania donovani | Ribosomal protein L27 |
| 26 | Z (Z) | uL15 | polymer | 145 | 16165.9 | 1 | UniProt (E9BSQ2) UniProt (by SIFTS) (A0A3Q8IGI9) | Leishmania donovani | 60S ribosomal protein L27A/L29 |
| 27 | AA (a) | eL28 | polymer | 147 | 16409.0 | 1 | UniProt (E9BAU9) UniProt (by SIFTS) (A0A3Q8I959) | Leishmania donovani | 60S ribosomal protein L28 |
| 28 | BA (b) | eL29 | polymer | 70 | 8001.3 | 1 | Leishmania donovani | Ribosomal protein L29 | |
| 29 | CA (c) | uL2 | polymer | 260 | 28321.9 | 1 | Leishmania donovani | ||
| 30 | DA (d) | uL3 | polymer | 419 | 47593.7 | 1 | Leishmania donovani | ||
| 31 | EA (e) | eL30 | polymer | 104 | 11400.3 | 1 | UniProt (E9BRQ6) UniProt (by SIFTS) (A0A3Q8IET6) | Leishmania donovani | 60S ribosomal protein L30 |
| 32 | FA (f) | eL31 | polymer | 183 | 20886.7 | 1 | UniProt (E9BSK4) | Leishmania donovani | 60S ribosomal subunit protein L31 |
| 33 | GA (g) | eL32 | polymer | 133 | 15397.0 | 1 | UniProt (E9BS76) UniProt (by SIFTS) (A0A3S7X954) | Leishmania donovani | 60S ribosomal protein L32 |
| 34 | HA (h) | eL34 | polymer | 168 | 19307.1 | 1 | UniProt (E9BUA1) UniProt (by SIFTS) (A0A3Q8IHK2) | Leishmania donovani | 60S ribosomal protein L34 |
| 35 | IA (i) | uL29 | polymer | 127 | 15232.2 | 1 | UniProt (E9BIP6) | Leishmania donovani | 60S ribosomal protein L35 |
| 36 | JA (j) | eL33 | polymer | 144 | 16492.3 | 1 | UniProt (E9BR22) UniProt (by SIFTS) (A0A3Q8II82) | Leishmania donovani | Ribosomal protein l35a |
| 37 | KA (k) | eL36 | polymer | 105 | 11959.2 | 1 | UniProt (E9BS63) UniProt (by SIFTS) (A0A3S7X961) | Leishmania donovani | 60S Ribosomal protein L36 |
| 38 | LA (l) | eL37 | polymer | 83 | 9862.6 | 1 | UniProt (P62885) | Leishmania donovani | 60S ribosomal protein L37 |
| 39 | MA (m) | eL43 | polymer | 92 | 10337.2 | 1 | UniProt (E9BFK4) | Leishmania donovani | 60S ribosomal protein L37a |
| 40 | NA (n) | eL38 | polymer | 83 | 9479.3 | 1 | UniProt (E9B7P2) | Leishmania donovani | Ribosomal protein L38 |
| 41 | OA (o) | eL39 | polymer | 51 | 6504.8 | 1 | UniProt (E9BCX6) | Leishmania donovani | 60S ribosomal protein L39 |
| 42 | PA (p) | uL4 | polymer | 373 | 41228.0 | 1 | UniProt (E9BKR3) UniProt (by SIFTS) (A0A3S5H7L0) | Leishmania donovani | Ribosomal protein L1a |
| 43 | QA (q) | eL40 | polymer | 128 | 14711.4 | 1 | UniProt (E9BMW6) UniProt (by SIFTS) (A0A3Q8ISR1) | Leishmania donovani | |
| 44 | RA (r) | eL42 | polymer | 106 | 12302.7 | 1 | UniProt (E9BBL5) | Leishmania donovani | 60S ribosomal protein L44 |
| 45 | SA (s) | uL18 | polymer | 305 | 34100.6 | 1 | UniProt (E9BS61) UniProt (by SIFTS) (A0A3Q8IJC5) | Leishmania donovani | 60S ribosomal protein L5 |
| 46 | TA (t) | eL6 | polymer | 195 | 21088.7 | 1 | Leishmania donovani | ||
| 47 | UA (u) | uL30 | polymer | 252 | 28915.0 | 1 | UniProt (E9BI29) | Leishmania donovani | 60S ribosomal protein L7 |
| 48 | VA (v) | eL8 | polymer | 348 | 39175.2 | 1 | UniProt (E9B949) | Leishmania donovani | 60S ribosomal protein L7a |
| 49 | WA (w) | uL6 | polymer | 190 | 21567.3 | 1 | UniProt (E9BFB5) UniProt (by SIFTS) (A0A3S7WWL2) | Leishmania donovani | 60S ribosomal protein L9 |
| 50 | XA (0) | eS1 | polymer | 264 | 30062.0 | 1 | UniProt (E9BRS2) | Leishmania donovani | 40S ribosomal protein S3a |
| 51 | YA (1) | eS4 | polymer | 273 | 30711.1 | 1 | UniProt (E9BBI6) UniProt (by SIFTS) (A0A3Q8I8K3) | Leishmania donovani | 40S ribosomal protein S4 |
| 52 | ZA (2) | 18S rRNA | polymer | 2205 | 710272.0 | 1 | GenBank (9504) | Leishmania donovani | |
| 53 | AB (3) | eS6 | polymer | 249 | 28370.2 | 1 | Leishmania donovani | ||
| 54 | BB (4) | eS7 | polymer | 200 | 23765.2 | 1 | Leishmania donovani | ||
| 55 | CB (5) | eS8 | polymer | 220 | 25066.4 | 1 | UniProt (E9BH78) UniProt (by SIFTS) (A0A3Q8ID68) | Leishmania donovani | 40S ribosomal protein S8 |
| 56 | DB (6) | uS4 | polymer | 190 | 22184.9 | 1 | UniProt (E9BTJ0) UniProt (by SIFTS) (A0A3S5H5Z2) | Leishmania donovani | 40S ribosomal protein S9 |
| 57 | EB (7) | RACK1 | polymer | 312 | 34459.5 | 1 | UniProt (Q9BIJ5) | Leishmania donovani | LACK protective antigen |
| 58 | FB (8) | uS14 | polymer | 57 | 6696.9 | 1 | UniProt (E9BJV7) | Leishmania donovani | Ribosomal protein S29 |
| 59 | GB (AC) | uS2 | polymer | 246 | 27536.6 | 1 | Leishmania donovani | ||
| 60 | HB (AD) | eS10 | polymer | 153 | 17432.9 | 1 | UniProt (E9BTG4) | Leishmania donovani | 40S ribosomal protein S10 |
| 61 | IB (AE) | uS17 | polymer | 173 | 19981.4 | 1 | Leishmania donovani | ||
| 62 | JB (AG) | uS15 | polymer | 151 | 17482.8 | 1 | Leishmania donovani | 40S ribosomal protein S13 | |
| 63 | KB (AH) | uS11 | polymer | 144 | 15623.2 | 1 | Leishmania donovani | 40S ribosomal protein S14 | |
| 64 | LB (AI) | uS19 | polymer | 152 | 17472.4 | 1 | Leishmania donovani | ||
| 65 | MB (AJ) | uS8 | polymer | 130 | 14719.3 | 1 | UniProt (E9BAV6) | Leishmania donovani | 40S ribosomal protein S15A |
| 66 | NB (AK) | uS9 | polymer | 149 | 16718.6 | 1 | UniProt (E9BI96) | Leishmania donovani | 40S ribosomal protein S16 |
| 67 | OB (AL) | eS17 | polymer | 143 | 16447.4 | 1 | Leishmania donovani | ||
| 68 | PB (AM) | uS13 | polymer | 153 | 17443.4 | 1 | UniProt (E9BTF9) | Leishmania donovani | 40S ribosomal protein S18 |
| 69 | QB (AN) | uS7 | polymer | 190 | 21336.6 | 1 | UniProt (Q868B1) Pfam (PF00177) | Leishmania donovani | |
| 70 | RB (AO) | eS19 | polymer | 179 | 20188.6 | 1 | UniProt (E9BR60) | Leishmania donovani | 40S ribosomal protein S19 protein |
| 71 | SB (AP) | uS5 | polymer | 265 | 28851.3 | 1 | Leishmania donovani | ||
| 72 | TB (AQ) | uS10 | polymer | 116 | 13032.0 | 1 | UniProt (E9BJI2) | Leishmania donovani | Ribosomal protein S20 |
| 73 | UB (AR) | eS21 | polymer | 164 | 17102.6 | 1 | Leishmania donovani | ||
| 74 | VB (AS) | uS12 | polymer | 143 | 15952.7 | 1 | Leishmania donovani | ||
| 75 | WB (AT) | eS24 | polymer | 137 | 15910.8 | 1 | Leishmania donovani | ||
| 76 | XB (AV) | eS26 | polymer | 112 | 12752.2 | 1 | Leishmania donovani | Ribosomal protein S26 | |
| 77 | YB (AW) | eS27 | polymer | 86 | 9803.5 | 1 | Leishmania donovani | 40S ribosomal protein S27-1 | |
| 78 | ZB (AX) | uS3 | polymer | 219 | 24541.8 | 1 | Leishmania donovani | ||
| 79 | AC (AY) | eS30 | polymer | 66 | 7394.9 | 1 | UniProt (E9BLG3) | Leishmania donovani | 40S ribosomal protein S30 |
| 80 | BC (AZ) | eS28 | polymer | 87 | 9705.2 | 1 | Leishmania donovani | 40S ribosomal protein S33 |
Sequence modifications
A: 1 - 1782 (GenBank: 322500086)
C: 1 - 261 (GenBank: 79677111)
G: 1 - 183 (GenBank: 5019758)
5: 1 - 220 (UniProt: E9BH78)
| PDB | External Database | Details |
|---|---|---|
| U 761 | A 1018169 | conflict |
| G 1393 | A 1017537 | conflict |
| - | A 1017504 | deletion |
| PDB | External Database | Details |
|---|---|---|
| C 141 | U 295 | conflict |
| G 182 | A 336 | conflict |
| C 185 | G 339 | conflict |
| A 226 | U 380 | conflict |
| C 228 | U 382 | conflict |
| C 246 | U 400 | conflict |
| PDB | External Database | Details |
|---|---|---|
| U 169 | A 597 | conflict |
| U 171 | A 599 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 220 | Lys 220 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 80 |
| Total formula weight | 3469652.1 | |
| All* | Total formula weight | 3469652.1 |
