5SZ9
Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Renin | polymer | 339 | 37153.9 | 2 | UniProt (P00797) Pfam (PF00026) | Homo sapiens (Human) | Angiotensinogenase |
| 2 | C, H (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 3 | D, I (A, B) | (azepan-1-yl)(2-{[(furan-2-yl)methyl]amino}-6-methylpyridin-3-yl)methanone | non-polymer | 313.4 | 2 | Chemie (74Y) PubChem (59625393) | |||
| 4 | E, F, G, K (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) PubChem (8117) | |||
| 5 | J (B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 159 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74307.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1643.9 | |
| All* | Total formula weight | 75951.6 |
