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5SJ3

Crystal Structure of human phosphodiesterase 10 in complex with [1-(4-chlorophenyl)-3-methylthieno[2,3-c]pyrazol-5-yl]-piperidin-1-ylmethanone

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Apolymer34339413.24UniProt (Q9Y233)
In PDB
Homo sapiens (human)
2A, B, C, DZINC IONnon-polymer65.44Chemie (ZN)
3A, B, C, DMAGNESIUM IONnon-polymer24.34Chemie (MG)
4A, BGLYCEROLnon-polymer92.13Chemie (GOL)
5A, B, C, D[1-(4-chlorophenyl)-3-methyl-1H-thieno[2,3-c]pyrazol-5-yl](piperidin-1-yl)methanonenon-polymer359.94Chemie (JX0)
6waterwater18.0706Chemie (HOH)
Sequence modifications
A, B, C, D: 449 - 789 (UniProt: Q9Y233)
PDBExternal DatabaseDetails
Gly 447-expression tag
Ser 448-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight157652.8
Non-Polymers*Number of molecules15
Total formula weight2074.6
All*Total formula weight159727.4
*Water molecules are not included.

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PDB entries from 2024-06-12

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