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5SHS

Crystal Structure of human phosphodiesterase 10 in complex with 3-(naphthalen-1-ylmethyl)-7-piperidin-1-yltriazolo[4,5-d]pyrimidine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Apolymer34339413.24UniProt (Q9Y233)
In PDB
Homo sapiens (human)
2A, B, C, DZINC IONnon-polymer65.44Chemie (ZN)
3A, B, C, DMAGNESIUM IONnon-polymer24.34Chemie (MG)
4AGLYCEROLnon-polymer92.11Chemie (GOL)
5A, B, C, D3-[(naphthalen-1-yl)methyl]-7-(piperidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidinenon-polymer344.44Chemie (JIS)
6waterwater18.0532Chemie (HOH)
Sequence modifications
A, B, C, D: 449 - 789 (UniProt: Q9Y233)
PDBExternal DatabaseDetails
Gly 447-expression tag
Ser 448-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight157652.8
Non-Polymers*Number of molecules13
Total formula weight1828.6
All*Total formula weight159481.4
*Water molecules are not included.

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PDB entries from 2024-06-12

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