5SGX
Crystal Structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-[2-methyl-5-[(2R)-2-(trifluoromethyl)pyrrolidin-1-yl]-1,2,4-triazol-3-yl]ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 343 | 39413.2 | 2 | UniProt (Q9Y233) In PDB | Homo sapiens (human) | |
2 | B, D | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 343 | 39489.3 | 2 | UniProt (Q9Y233) In PDB | Homo sapiens (human) | |
3 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
4 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
5 | A, B, C, D | (4S)-5,8-dimethyl-2-(2-{1-methyl-3-[(2R)-2-(trifluoromethyl)pyrrolidin-1-yl]-1H-1,2,4-triazol-5-yl}ethyl)[1,2,4]triazolo[1,5-c]pyrimidine | non-polymer | 394.4 | 4 | Chemie (IZH) | |||
6 | water | water | 18.0 | 788 | Chemie (HOH) |
Sequence modifications
A, C: 449 - 789 (UniProt: Q9Y233)
B, D: 449 - 789 (UniProt: Q9Y233)
PDB | External Database | Details |
---|---|---|
Gly 447 | - | expression tag |
Ser 448 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 447 | - | expression tag |
Ser 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 157805.1 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1936.4 | |
All* | Total formula weight | 159741.5 |