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5SGP

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c4(c(C(Nc2cc1nc(cn1cc2)c3ccccc3)=O)n(nc4)C)C(=O)N(C)CCOC, micromolar IC50=0.022639

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Apolymer34339413.24UniProt (Q9Y233)Homo sapiens (human)
2E, I, L, O
(A, B, C, D)
ZINC IONnon-polymer65.44Chemie (ZN)
3F, J, M, P
(A, B, C, D)
MAGNESIUM IONnon-polymer24.34Chemie (MG)
4G
(A)
GLYCEROLnon-polymer92.11Chemie (GOL)
5H, K, N, Q
(A, B, C, D)
N~4~-(2-methoxyethyl)-N~4~,1-dimethyl-N~5~-[(4R)-2-phenylimidazo[1,2-a]pyridin-7-yl]-1H-pyrazole-4,5-dicarboxamidenon-polymer432.54Chemie (IYD)
6R, S, T, U
(A, B, C, D)
waterwater18.0721Chemie (HOH)
Sequence modifications
A, B, C, D: 449 - 789 (UniProt: Q9Y233)
PDBExternal DatabaseDetails
Gly 447-expression tag
Ser 448-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight157652.8
Non-Polymers*Number of molecules13
Total formula weight2180.8
All*Total formula weight159833.7
*Water molecules are not included.

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PDB entries from 2024-10-30

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