Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5SG7

Crystal Structure of human phosphodiesterase 10 in complex with 3-[2-(2-fluorophenyl)pyrazol-3-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4-one

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Apolymer34339337.14UniProt (Q9Y233)
In PDB
Homo sapiens (human)
2A, B, C, D3-[1-(2-fluorophenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-onenon-polymer400.34Chemie (IVY)
3A, B, C, DZINC IONnon-polymer65.44Chemie (ZN)
4A, B, C, DMAGNESIUM IONnon-polymer24.34Chemie (MG)
5waterwater18.0514Chemie (HOH)
Sequence modifications
A, B, C, D: 449 - 789 (UniProt: Q9Y233)
PDBExternal DatabaseDetails
Gly 447-expression tag
Ser 448-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight157348.3
Non-Polymers*Number of molecules12
Total formula weight1960.2
All*Total formula weight159308.5
*Water molecules are not included.

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon