5SFF

Crystal Structure of human phosphodiesterase 10 in complex with [2-methyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethynyl]imidazo[1,2-b]pyridazin-3-yl]methanol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	polymer	343	39413.2	4	UniProt (Q9Y233) In PDB	Homo sapiens (human)
2	A, B, C, D	{(4S)-2-methyl-6-[(1-methyl-4-phenyl-1H-imidazol-2-yl)ethynyl]imidazo[1,2-b]pyridazin-3-yl}methanol	non-polymer		343.4	4	Chemie (IKH)
3	A, B, C, D	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	A, B, C, D	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
5		water	water		18.0	333	Chemie (HOH)

Sequence modifications

A, B, C, D: 449 - 789 (UniProt: Q9Y233)

PDB	External Database	Details
Gly 447	-	expression tag
Ser 448	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	157652.8
Non-Polymers*	Number of molecules	12
	Total formula weight	1732.4
All*	Total formula weight	159385.2

*Water molecules are not included.