Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5SFD

Crystal Structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-(2-methyl-5-piperidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Apolymer34339413.24UniProt (Q9Y233)
In PDB
Homo sapiens (human)
2A, B, C, DZINC IONnon-polymer65.44Chemie (ZN)
3A, B, C, DMAGNESIUM IONnon-polymer24.34Chemie (MG)
4A, B, C, D(4S)-5,8-dimethyl-2-{2-[1-methyl-3-(piperidin-1-yl)-1H-1,2,4-triazol-5-yl]ethyl}[1,2,4]triazolo[1,5-a]pyrazinenon-polymer340.44Chemie (IKB)
5waterwater18.0424Chemie (HOH)
Sequence modifications
A, B, C, D: 449 - 789 (UniProt: Q9Y233)
PDBExternal DatabaseDetails
Gly 447-expression tag
Ser 448-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight157652.8
Non-Polymers*Number of molecules12
Total formula weight1720.6
All*Total formula weight159373.4
*Water molecules are not included.

222036

PDB entries from 2024-07-03

PDB statisticsPDBj update infoContact PDBjnumon