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5SE1

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c1(nn(cc1NC(c2nc(ccc2Nc3cncnc3)C4CC4)=O)C)C(=O)N(C)C, micromolar IC50=0.031527

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Apolymer34339413.21UniProt (Q9Y233)Homo sapiens (human)
2B
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
3C
(A)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
4D
(A)
6-cyclopropyl-N-[3-(dimethylcarbamoyl)-1-methyl-1H-pyrazol-4-yl]-3-[(pyrimidin-5-yl)amino]pyridine-2-carboxamidenon-polymer406.41Chemie (IBV)
5E
(A)
waterwater18.088Chemie (HOH)
Sequence modifications
A: 449 - 789 (UniProt: Q9Y233)
PDBExternal DatabaseDetails
Gly 447-expression tag
Ser 448-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight39413.2
Non-Polymers*Number of molecules3
Total formula weight496.2
All*Total formula weight39909.4
*Water molecules are not included.

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PDB entries from 2024-11-20

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