5SE1
CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c1(nn(cc1NC(c2nc(ccc2Nc3cncnc3)C4CC4)=O)C)C(=O)N(C)C, micromolar IC50=0.031527
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (A) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 343 | 39413.2 | 1 | UniProt (Q9Y233) | Homo sapiens (human) | |
2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
4 | D (A) | 6-cyclopropyl-N-[3-(dimethylcarbamoyl)-1-methyl-1H-pyrazol-4-yl]-3-[(pyrimidin-5-yl)amino]pyridine-2-carboxamide | non-polymer | 406.4 | 1 | Chemie (IBV) | |||
5 | E (A) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A: 449 - 789 (UniProt: Q9Y233)
PDB | External Database | Details |
---|---|---|
Gly 447 | - | expression tag |
Ser 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 39413.2 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 496.2 | |
All* | Total formula weight | 39909.4 |