5SD7
Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-735
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydrofolate reductase | polymer | 187 | 21480.7 | 1 | UniProt (P00374) Pfam (PF00186) In PDB | Homo sapiens (human) | |
| 2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | A | (2S)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanoic acid | non-polymer | 374.4 | 1 | Chemie (I0E) | |||
| 4 | A | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 7 | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21480.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1657.3 | |
| All* | Total formula weight | 23138.0 |
