5SCI
Structure of liver pyruvate kinase in complex with anthraquinone derivative 105
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Pyruvate kinase | polymer | 447 | 48285.4 | 8 | UniProt (Q16716) Pfam (PF00224) Pfam (PF02887) UniProt (by SIFTS) (P30613) | Homo sapiens (human) | |
| 2 | EA, I, JA, M, OA... (F, A, G, B, H...) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 8 | Chemie (FBP) | |||
| 3 | AA, FA, J, KA, N... (E, F, A, G, B...) | OXALATE ION | non-polymer | 88.0 | 8 | Chemie (OXL) | |||
| 4 | BA, GA, K, LA, O... (E, F, A, G, B...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 5 | CA, HA, L, MA, P... (E, F, A, G, B...) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 6 | DA, IA, NA, U (E, F, G, C) | dimethyl (2R)-2-hydroxy-2-{2-[4-(3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)piperazin-1-yl]-2-oxoethyl}butanedioate | non-polymer | 574.6 | 4 | Chemie (I9F) | |||
| 7 | SA, TA, UA, VA, WA... (A, B, C, D, E...) | water | water | 18.0 | 1591 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 129 (UniProt: Q16716)
A, B, C, D, E, F, G, H: 231 - 543 (UniProt: Q16716)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asp 12 | Ser 35 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 130 | - | linker |
| Ser 131 | - | linker |
| Gly 132 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 386283.0 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 6230.5 | |
| All* | Total formula weight | 392513.6 |
