5SCC

Structure of liver pyruvate kinase in complex with anthraquinone derivative 57

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Pyruvate kinase	polymer	447	48285.4	8	UniProt (Q16716) Pfam (PF00224) Pfam (PF02887) UniProt (by SIFTS) (P30613) In PDB	Homo sapiens (human)
2	F, A, G, B, H...	1,6-di-O-phosphono-beta-D-fructofuranose	non-polymer		340.1	8	Chemie (FBP)
3	E, F, A, G, B...	OXALATE ION	non-polymer		88.0	8	Chemie (OXL)
4	E, F, A, G, B...	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
5	E, F, A, G, B...	POTASSIUM ION	non-polymer		39.1	8	Chemie (K)
6	F, G, C	4-amino-3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid	non-polymer		319.3	3	Chemie (I8Q)
7		water	water		18.0	2332	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 129 (UniProt: Q16716)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag
Asp 12	Ser 35	conflict

A, B, C, D, E, F, G, H: 231 - 543 (UniProt: Q16716)

PDB	External Database	Details
Gly 130	-	linker
Ser 131	-	linker
Gly 132	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	386283.0
Non-Polymers*	Number of molecules	35
	Total formula weight	4890.2
All*	Total formula weight	391173.2

*Water molecules are not included.