5SC9

Structure of liver pyruvate kinase in complex with anthraquinone derivative 29

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Pyruvate kinase	polymer	447	48285.4	8	UniProt (Q16716) Pfam (PF00224) Pfam (PF02887) UniProt (by SIFTS) (P30613)	Homo sapiens (human)
2	CA, HA, I, LA, M... (F, G, A, H, B...)	1,6-di-O-phosphono-beta-D-fructofuranose	non-polymer		340.1	8	Chemie (FBP)
3	DA, IA, J, MA, N... (F, G, A, H, B...)	OXALATE ION	non-polymer		88.0	8	Chemie (OXL)
4	AA, EA, JA, K, NA... (E, F, G, A, H...)	1-(3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonyl)piperidine-4-carboxylic acid	non-polymer		431.4	7	Chemie (I7K)
5	BA, FA, GA, KA, L... (E, F, G, A, B...)	MAGNESIUM ION	non-polymer		24.3	10	Chemie (MG)
6	PA, QA, RA, SA, TA... (A, B, C, D, E...)	water	water		18.0	3128	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 129 (UniProt: Q16716)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag
Asp 12	Ser 35	conflict

A, B, C, D, E, F, G, H: 231 - 543 (UniProt: Q16716)

PDB	External Database	Details
Gly 228	-	linker
Ser 229	-	linker
Gly 230	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	386283.0
Non-Polymers*	Number of molecules	33
	Total formula weight	6688.0
All*	Total formula weight	392971.1

*Water molecules are not included.