5QJ0
CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RNA-dependent RNA polymerase | polymer | 574 | 63931.4 | 1 | UniProt (R9THT8) Pfam (PF00998) UniProt (by SIFTS) (Q99IB8) | Hepacivirus C | |
| 2 | B (A) | 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide | non-polymer | 627.7 | 1 | Chemie (J6D) | |||
| 3 | C, D, E (A) | THIOCYANATE ION | non-polymer | 58.1 | 3 | Chemie (SCN) | |||
| 4 | F (A) | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 1 | Chemie (2PE) | |||
| 5 | G, H, I, J, K (A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 6 | L (A) | water | water | 18.0 | 458 | Chemie (HOH) |
Sequence modifications
A: 1 - 573 (UniProt: R9THT8)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 30 | Leu 2472 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 63931.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1676.9 | |
| All* | Total formula weight | 65608.3 |
