5QIK
TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-{4-[3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | TGF-beta receptor type-1 | polymer | 307 | 35165.5 | 1 | UniProt (P36897) Pfam (PF00069) In PDB | Homo sapiens (Human) | TGFR-1,Activin A receptor type II-like protein kinase of 53kD,Activin receptor-like kinase 5,ALK5,Serine/threonine-protein kinase receptor R4,SKR4,TGF-beta type I receptor,Transforming growth factor-beta receptor type I,TbetaR-I |
| 2 | A | N-{4-[3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide | non-polymer | 365.4 | 1 | Chemie (J2M) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence modifications
A: 200 - 503 (UniProt: P36897)
| PDB | External Database | Details |
|---|---|---|
| Gly 197 | - | expression tag |
| His 198 | - | expression tag |
| Met 199 | - | expression tag |
| Asp 204 | Thr 204 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35165.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 549.5 | |
| All* | Total formula weight | 35715.0 |
