5QDD
Crystal structure of BACE complex with BMC020 hydrolyzed
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Beta-secretase 1 | polymer | 402 | 44777.3 | 3 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (Human) | Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 |
| 2 | A, B, C | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 3 | A, B, C | (10R,12S)-12-[(1R)-1,2-dihydroxyethyl]-N,N,10-trimethyl-14-oxo-2-oxa-13-azabicyclo[13.3.1]nonadeca-1(19),15,17-triene-17-carboxamide | non-polymer | 420.5 | 3 | Chemie (E7A) | |||
| 4 | water | water | 18.0 | 311 | Chemie (HOH) |
Sequence modifications
A, B, C: -13 - 386 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Gly -15 | - | expression tag |
| Pro -14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 134332.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1537.9 | |
| All* | Total formula weight | 135869.9 |
