5QD5
Crystal structure of BACE complex with BMC009
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Beta-secretase 1 | polymer | 402 | 44777.3 | 3 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (Human) | Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 |
2 | A, B, C | (10S,12S)-17-chloro-12-[(1R)-1-hydroxy-2-({[3-(propan-2-yl)phenyl]methyl}amino)ethyl]-10-methyl-7-oxa-2,13,18-triazabicyclo[13.3.1]nonadeca-1(19),15,17-trien-14-one | non-polymer | 517.1 | 3 | Chemie (E6P) | |||
3 | water | water | 18.0 | 369 | Chemie (HOH) |
Sequence modifications
A, B, C: -13 - 386 (UniProt: P56817)
PDB | External Database | Details |
---|---|---|
Gly -15 | - | expression tag |
Pro -14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 134332.0 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1551.3 | |
All* | Total formula weight | 135883.3 |