5QCT
Crystal structure of BACE complex with BMC001
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Beta-secretase 1 | polymer | 402 | 44777.3 | 3 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (Human) | Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 |
2 | A, B, C | (2R,4S)-N-butyl-4-[(4S,6R)-16-ethoxy-12-ethyl-6-methyl-2,13-dioxo-3,12-diazabicyclo[12.3.1]octadeca-1(18),14,16-trien-4-yl]-4-hydroxy-2-methylbutanamide | non-polymer | 531.7 | 3 | Chemie (E4Y) | |||
3 | C | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
4 | water | water | 18.0 | 344 | Chemie (HOH) |
Sequence modifications
A, B, C: -13 - 386 (UniProt: P56817)
PDB | External Database | Details |
---|---|---|
Gly -15 | - | expression tag |
Pro -14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 134332.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1690.2 | |
All* | Total formula weight | 136022.2 |