5QCS
Crystal structure of BACE complex with BMC024
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Beta-secretase 1 | polymer | 402 | 44777.3 | 3 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (Human) | Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 |
2 | A, B, C | (2R,4S)-N-BUTYL-4-HYDROXY-2-METHYL- 4-((E)-(4AS,12R,15S,17AS)-15-METHYL -14,17-DIOXO-2,3,4,4A,6,9,11,12,13, 14,15,16,17,17A-TETRADECAHYDRO-1H-5 ,10-DITHIA-1,13,16-TRIAZA-BENZOCYCL OPENTADECEN-12-YL)-BUTYRAMIDE | non-polymer | 514.7 | 3 | Chemie (AXF) | |||
3 | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence modifications
A, B, C: -13 - 386 (UniProt: P56817)
PDB | External Database | Details |
---|---|---|
Gly -15 | - | expression tag |
Pro -14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 134332.0 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1544.2 | |
All* | Total formula weight | 135876.2 |